What It Does
Vitex is one of the most researched botanicals in women’s health. Vitex interacts with signaling pathways to support cycle regularity and overall comfort.

Why This Form
SilentCycle™ uses a standardized extract containing 0.5% agnusides, the key bioactive compounds. Generic chasteberry powders can vary widely in potency. Standardization ensures consistent and predictable amounts in each serving.

Why This Dose
Published research commonly uses daily Vitex extract across multiple cycles. The 30 mg aligns with commonly studied dosing ranges used for consistent daily support.

Clinical References
Verkaik, S., et al. (2017). Vitex agnus castus for premenstrual syndrome: A systematic review and meta-analysis. American Journal of Obstetrics & Gynecology, 217(2), 150–166.

Schellenberg, R. (2001). Treatment for the premenstrual syndrome with agnus castus fruit extract: Prospective, randomized, placebo-controlled study. BMJ, 322(7279), 134–137.

Csupor, D., et al. (2019). Vitex agnus-castus in premenstrual syndrome: A meta-analysis of double-blind randomized controlled trials. Phytomedicine, 60, 152962.

What It Does
Magnesium has been studied for its ability to support neuromuscular relaxation and stress regulation.

Why This Form
Many supplements use magnesium oxide, which is poorly absorbed and can cause digestive discomfort. SilentCycle™ uses magnesium bisglycinate, a highly bioavailable and well-tolerated form bound to glycine. This form supports better absorption while being gentler on digestion.

Why This Dose
Published studies often use daily magnesium supplementation across cycles to support muscular relaxation as part of a multi-ingredient strategy.

Clinical References
Facchinetti, F., et al. (1991). Oral magnesium successfully relieves premenstrual mood changes. Obstetrics & Gynecology, 78(2), 177–181.

Ebrahimi, E., et al. (2012). Effect of magnesium and vitamin B6 supplementation on the
severity of premenstrual syndrome symptoms. Iranian Journal of Nursing and Midwifery Research, 17(2), 131–135.

What It Does
Saffron has been studied for its ability to support emotional balance and positive mood throughout the menstrual cycle.

Why This Form
SilentCycle™ uses a standardized saffron extract (0.3%), ensuring consistent levels of key bioactive compounds. Standardization is essential with botanical ingredients to provide predictable potency and reliable support.

Why This Dose
30mg daily is a commonly studied amount in published studies of saffron's mood support.

Clinical References
Agha-Hosseini, M., et al. (2008). Crocus sativus L. (saffron) in the treatment of premenstrual syndrome. BJOG, 115(4), 515–519.

Rajabi, S., et al. (2020). Comparison of saffron and fluoxetine in premenstrual dysphoric disorder. Journal of Psychosomatic Obstetrics & Gynecology, 41(2), 134–140.

What It Does
P-5-P is the active form of Vitamin B6, which is essential for the production of neurotransmitters like serotonin and dopamine, which regulate mood and stress.

Why This Form
SilentCycle™ uses Pyridoxal-5-Phosphate (P-5-P), the biologically active form of vitamin B6. Unlike pyridoxine HCl, which must be converted in the liver before use, P-5-P is ready to immediately support your mind and body.

Why This Dose
Published research evaluating Vitamin B6 for mood support often use moderate daily dosing. SilentCycle™ provides 20mg of active P-5-P to effectively support a balanced mood.

Clinical References
Wyatt, K. M., et al. (1999). Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: Systematic review. BMJ, 318(7195), 1375–1381.

Doll, H., et al. (1989). Pyridoxine (vitamin B6) and the premenstrual syndrome: A
randomized crossover trial. Journal of the Royal College of General Practitioners, 39, 364–368.

What It Does
L-theanine promotesa calm, focused state by supporting healthy alpha brain wave activity without causing drowsiness.

Why This Form
Unlike mild herbal calming blends, pure L-theanine has published research demonstrating its supporting role in mind and body relaxation.

Why This Dose
200mg is a dose commonly used in published research. This amount is intended to support calm focus and stress modulation.

Clinical References
Hidese, S., et al. (2019). Effects of L-theanine administration on stress-related symptoms and cognitive function. Nutrients, 11(10), 2362.

Evans, M., et al. (2021). Acute effects of L-theanine on stress response. Nutrients, 13(6), 2063.

What It Does
Ginger supports digestive health and overall comfort throughout the menstrual cycle

Why This Form
SilentCycle™ uses a standardized 5% ginger extract, providing consistent active compounds rather than raw powder with variable potency.

Why This Dose
The 250 mg extract dose is consistent with published research showing ginger's role is supporting gut wellness and overall cycle comfort.

Clinical References
Daily, J. W., et al. (2015). Efficacy of ginger for dysmenorrhea: Systematic review and meta-analysis. Pain Medicine, 16(12), 2243–2255.

Rahnama, P., et al. (2012). Effect of ginger on dysmenorrhea. BMC Complementary and
Alternative Medicine, 12, 92.